Dr. Marie Labouesse

Forschungsgebiet

I currently lead the Brain, Wire and Behavior Groupcall_made  at ETH Zurich. We are a Neuroscience-focused Research Group hosted by the Laboratory of Translational Nutritional Biology at ETHZ led by Prof. Christian Wolfrum. My team is funded by the Swiss National Science Foundation (SNSF Ambizione Grant), the Zurich Neuroscience Center (ZNZ), the Brain and Behavior Research Foundation (BBRF), among others.

Our work aims to understand how brain circuits control reward and aversion behavior in animal models. On the one hand we study how subcircuits in the basal ganglia acutely regulate reward and aversion behavior in adulthood. On the other hand we investigate how alterations in basal ganglia circuits during adolescence can shape behavior into adulthood and increase the risk for neuropsychiatric symptoms. To conduct our work, we use a combination of in vivo fluorescent brain imaging (photometry + matlab-based time-series analyses), biosensors, viral vectors, optogenetics, chemogenetics, neuropharmacology, neuroanatomical tracing, behavioral assays, deep-learning-based behavioral tracking (deeplabcut), transcriptomic analyses, and transgenic mouse models.

Selected publications

Labouesse MA, Torres-Herraez A, Chohan MO, et al., Kellendonk C. A non-canonical striatopallidal Go pathway that supports motor control. https://doi.org/10.21203/rs.3.rs-2524816/v1call_made Nature Communications; 2023; In press.

Martyniuk K, Torres-Herraez A, Lowes DC, Rubenstein M, Labouesse MA, Kellendonk C. Dopamine D2Rs Coordinate Cue-Evoked Changes in Striatal Acetylcholine Levels. eLife 2022; https://elifesciences.org/articles/76111call_made

Labouesse MA, Patriarchi T. A versatile GPCR toolkit to track in vivo neuromodulation: not a one-size-fits-all sensor. Neuropsychopharmacology. 2021; 10.1038 / s41386-021-00982-y. https://doi.org/10.1038/s41386-021-00982-ycall_made   

Labouesse MA*, Cola R*, Patriarchi T. GPCR-based dopamine sensors: a detailed guide to inform sensor choice for in vivo imaging. IJMS. 2020; 21:8048. https://www.mdpi.com/1422-0067/21/21/8048call_made  * shared first authorship

Labouesse MA, Sartori A, et al., Kellendonk C, Weber-Stadlbauer U. Striatal dopamine 2 receptor upregulation during development predisposes to diet-induced obesity by reducing energy output in mice. Proceedings of the National Academy of Sciences. 2018; 115: 10493-10498. http://www.pnas.org/content/115/41/10493.longcall_made

Labouesse MA, Lassalle O, et al., Langhans W, Chavis P †, Meyer U †. Hypervulnerability of the adolescent prefrontal cortex to nutritional stress via reelin deficiency. Molecular Psychiatry . 2017. 22: 961–971. † shared senior authorship. http://dx.doi.org/10.1038/mp.2016.193call_made

Full list of publications: https://pubmed.ncbi.nlm.nih.gov/?term=labouesse-macall_made